大唐盛世，万国来朝，唐朝皇帝举办万邦蹴鞠大赛以示国力昌盛，此时喧闹的长安城里，龙门客栈的一众人物又开始了忙碌的一天：老板娘铁掌柜（黄奕饰）借蹴鞠大赛克扣员工薪水，爱财的劳保安（孙兴饰）在停马场中饱私囊，仗义行侠的芙蓉姐（应采儿饰）再惹祸端，客栈伙计白砂糖（邱胜翊饰）盲打误撞参加盗圣大冲关比赛，并从盗圣孙午饭（何炅饰）手中夺得盗圣牌。另一边，皇帝答应了西方来客的请求，派出马拉松冠军向被魔物掌控的国家送去圣火。仰慕唐僧的唐三句（徐铮饰）此时正苦于找不到搭档一起重走西天取经路，这时，因失去盗圣牌而短暂失忆的孙午饭、渴望成为舞蹈家的龙门客栈服务员朱八姐（谢娜饰）先后与唐三句结识，三个痛苦的人决定同去西方解决自己的问题。而一场龙门客栈的大火，令送圣火的任务，还有龙门客栈众人都加入了这次西行…

During the prosperity of the Tang Dynasty, all nations came to the dynasty, and the emperor of the Tang Dynasty held the Wanbang Cuju Competition to show the prosperity of the country. At this time, in the noisy city of Chang'an, the Dragon Inn A group of characters have started another busy day: the proprietress Tie Shopkeeper (played by Huang Yi) deducts the salaries of employees by taking advantage of the Cuju competition, the money-loving labor security guard (played by Sun Xing) fills his own pockets in the racetrack, and the heroic sister Furong (played by Ying Caier) Getting into trouble again, the inn clerk Bai Shatang (played by Qiu Shengyi) blindly and mistakenly participated in the Grand Pirates Grand Prix Competition, and won the Stealing Holy Card from the Thief Sun Luncheon (played by He Jiong). On the other hand, the emperor agreed to the request of the visitors from the west and sent the marathon champion to send the torch to the country controlled by the monster. At this time, Tang Sanju (played by Xu Zheng), who admired Tang Seng, was struggling to find a partner to re-walk the path of learning the scriptures in the West. (Xie Na) got acquainted with Tang Sanju successively, and the three suffering people decided to go to the West together to solve their own problems. And a big fire at the Longmen Inn, the task of sending the torch, and everyone at the Longmen Inn joined this westward journey...